Metabolic disconnection between the mediodorsal nucleus of the thalamus and cortical Brodmann's areas of the left hemisphere in schizophrenia

被引：61

作者：

Mitelman, SA ^{[1
]}

Byne, W ^{[1
]}

Kemether, EM ^{[1
]}

Hazlett, EA ^{[1
]}

Buchsbaum, MS ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA

来源：

AMERICAN JOURNAL OF PSYCHIATRY | 2005年 / 162卷 / 09期

关键词：

D O I：

10.1176/appi.ajp.162.9.1733

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia. Method: They used [F-18] fluorodeoxyglucose positron emission tomography in 41 unmedicated patients with schizophrenia and 59 normal comparison subjects. Results: A metabolic disconnection was observed in patients with schizophrenia in the left hemisphere between the mediodorsal nucleus and widespread frontotemporal cortical regions, and stronger-than-normal intercorrelations were found between the pulvinar and superior temporal, selected parietal, posterior cingulate, and occipital areas. Conclusions: Deficits in the functional interrelationships between the left frontotemporal cortices and the left mediodorsal nucleus of the thalamus complement inferences from postmortem and magnetic resonance imaging volumetric studies identifying a thalamic diathesis in schizophrenia.

引用

页码：1733 / 1735

页数：3

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