A core promoter element downstream of the TATA box that is recognized by TFIIB

被引：109

作者：

Deng, WS ^{[1
]}

Roberts, SGE ^{[1
]}

机构：

[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England

来源：

GENES & DEVELOPMENT | 2005年 / 19卷 / 20期

基金：

英国惠康基金;

关键词：

transcription; RNA polymerase II; TFIIB; promoter;

D O I：

10.1101/gad.342405

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have defined a core promoter element downstream of the TATA box that is recognized by TFIIB. This involves a DNA-binding domain in TFIIB that is distinct from the helix-turn-helix motif (which recognizes an element upstream of the TATA box). The TFIIB recognition element we describe regulates transcription in a manner that is promoter context-dependent, particularly with respect to the TFIIB recognition element that is located upstream of the TATA box. Thus TFIIB can recognize two distinct sequence elements that flank the TATA box, employing independent DNA-binding motifs and cooperating in the regulation of transcription.

引用

页码：2418 / 2423

页数：6

共 22 条

[1] Ausubel FM, 1995, SHORT PROTOCOLS MOL
[2] Identification and distinct regulation of yeast TATA box-containing genes
Basehoar, AD
Zanton, SJ
Pugh, BF
[J]. CELL, 2004, 116 (05) : 699 - 709
[3] Orientation of the transcription preinitiation complex in Archaea
Bell, SD
Kosa, PL
Sigler, PB
Jackson, SP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) : 13662 - 13667
[4] Role of the RNA polymerase sigma subunit in transcription initiation
Borukhov, S
Severinov, K
[J]. RESEARCH IN MICROBIOLOGY, 2002, 153 (09) : 557 - 562
[5] The RNA polymerase II core promoter: a key component in the regulation of gene expression
Butler, JEF
Kadonaga, JT
[J]. GENES & DEVELOPMENT, 2002, 16 (20) : 2583 - 2592
[6] Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates
Chen, Z
Manley, JL
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (20) : 7350 - 7362
[7] Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB
Evans, R
Fairley, JA
Roberts, SGE
[J]. GENES & DEVELOPMENT, 2001, 15 (22) : 2945 - 2949
[8] Core promoter-dependent TFIIB conformation and a role for TFIIB conformation in transcription start site selection
Fairley, JA
Evans, R
Hawkes, NA
Roberts, SGE
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (19) : 6697 - 6705
[9] MULTIPLE FUNCTIONAL DOMAINS OF HUMAN TRANSCRIPTION FACTOR-IIB - DISTINCT INTERACTIONS WITH 2 GENERAL TRANSCRIPTION FACTORS AND RNA POLYMERASE-II
HA, I
ROBERTS, S
MALDONADO, E
SUN, XQ
KIM, LU
GREEN, M
REINBERG, D
[J]. GENES & DEVELOPMENT, 1993, 7 (06) : 1021 - 1032
[10] Structure and mechanism of the RNA polymerase II transcription machinery
Hahn, S
[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (05) : 394 - 403

← 1 2 3 →