Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells

被引：73

作者：

Peifer, M

Yap, AS

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[4] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia

来源：

JOURNAL OF CELL BIOLOGY | 2003年 / 163卷 / 03期

关键词：

D O I：

10.1083/jcb.200310090

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Proteins of the p120 family have been implicated in the regulation of cadherin-based cell adhesion, but their relative importance in this process and their mechanism of action have remained less clear. Three papers in this issue suggest that p120 plays a key role in maintaining normal levels of cadherin in mammalian cells, and that it may do so by regulating cadherin trafficking.

引用

页码：437 / 440

页数：4

共 21 条

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[2] Angst BD, 2001, J CELL SCI, V114, P629
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Chen, XY
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[J]. JOURNAL OF CELL BIOLOGY, 2003, 163 (03) : 547 - 557
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[7] Minimal mutation of the cytoplasmic tail inhibits the ability of E-cadherin to activate Rac but not phosphatidylinositol 3-kinase - Direct evidence of a role for cadherin-activated Rac signaling in adhesion and contact formation
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