A case of fatal aconitine poisoning by monkshood ingestion

被引：58

作者：

Pullela, Ravi ^{[1
]}

Young, Lorraine ^{[2
]}

Gallagher, Barry ^{[3
]}

Avis, Simon P. ^{[4
]}

Randell, Edward W. ^{[1
,2
,4
]}

机构：

[1] Mem Univ Newfoundland, Dept Biochem, Fac Sci, St John, NF A1B 3X9, Canada

[2] Eastern Hlth Author, Hlth Sci Ctr, Lab Med, St John, NF A1B 3V6, Canada

[3] James Paton Mem Hosp, Gander, NF A1B 3V6, Canada

[4] Mem Univ Newfoundland, Fac Med, Hlth Sci Ctr, Lab Med, St John, NF A1B 3V6, Canada

来源：

JOURNAL OF FORENSIC SCIENCES | 2008年 / 53卷 / 02期

关键词：

forensic science; toxicology; aconitine; monkshood; tandem mass spectrometry;

D O I：

10.1111/j.1556-4029.2007.00647.x

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 [法学]; 10 [医学];

摘要：

Accidental aconitine poisoning is extremely rare in North America. This report describes the confirmation of a case of accidental aconitine poisoning using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method. The case involved a 25-year-old man who died suddenly following a recreational outing with friends where he consumed a number of wild berries and plants including one that was later identified as Monkshood (Aconitum napellus). Postmortem blood and urine samples were available for analysis. All routine urine and blood toxicology screens were negative. The LC-MS/MS method allowed sensitive quantification of aconitine, the main toxin in A. napellus, and showed 3.6 and 149 mu g/L in blood and urine, respectively. These concentrations were similar to that reported in other aconitine-related deaths. This case illustrates the dangers of consuming unidentified plants, and documents concentrations of aconitine in blood and urine in a fatal case of A. napallus-related poisoning.

引用

页码：491 / 494

页数：4

共 13 条

[1]

The effects of Aconitum alkaloids on the central nervous system [J].

Ameri, A .

PROGRESS IN NEUROBIOLOGY, 1998, 56 (02) :211-235

[2]

Plant exposures: wilderness medicine [J].

Dyer, S .

EMERGENCY MEDICINE CLINICS OF NORTH AMERICA, 2004, 22 (02) :299-+

[3]

A case of fatal poisoning with the aconite plant: quantitative analysis in biological fluid [J].

Elliott, SP .

SCIENCE & JUSTICE, 2002, 42 (02) :111-115

[4]

Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation-contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes [J].

Fu, Min ;

Wu, Meng ;

Wang, Ji-Feng ;

Qiao, Yan-Jiang ;

Wang, Zhao .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 354 (04) :929-936

[5]

Distribution of Aconitum alkaloids in body fluids and tissues in a suicidal case of aconite ingestion [J].

Ito, K ;

Tanaka, S ;

Funayama, M ;

Mizugaki, M .

JOURNAL OF ANALYTICAL TOXICOLOGY, 2000, 24 (05) :348-353

[6]

Clinical features and management of herb-induced aconitine poisoning [J].

Lin, CC ;

Chan, TYK ;

Deng, JF .

ANNALS OF EMERGENCY MEDICINE, 2004, 43 (05) :574-579

[7]

Quantitative analysis of Aconitum alkaloids in the urine and serum of a male attempting suicide by oral intake of aconite extract [J].

Mizugaki, M ;

Ito, K ;

Ohyama, Y ;

Konishi, Y ;

Tanaka, S ;

Kurasawa, K .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1998, 22 (04) :336-340

[8]

Moffat A.C., 2004, CLARKES ANAL DRUGS P, V2

[9]

Mori A, 1990, Nihon Hoigaku Zasshi, V44, P352

[10]

Severe acute poisoning with homemade Aconitum napellus capsules:: Toxicokinetic and clinical data [J].

Moritz, F ;

Compagnon, P ;

Kaliszczak, IG ;

Kaliszczak, Y ;

Caliskan, V ;

Girault, C .

CLINICAL TOXICOLOGY, 2005, 43 (07) :873-876

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