Tissue factor-bearing microparticles and cancer

被引：53

作者：

Zwicker, Jeffrey I. ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Hematol Oncol, Boston, MA 02215 USA

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2008年 / 34卷 / 02期

关键词：

cancer thrombosis; microparticles; tissue factor-bearing microparticles;

D O I：

10.1055/s-2008-1079260

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood-borne tissue factor (TF)-bearing microparticles have been shown to play an important role in thrombus propagation in experimental models. The pathophysiologic role of these microparticles is being investigated in several prothrombotic conditions including cancer-associated thrombosis. Tumor cells are known to shed TF-bearing microparticles in vitro, and circulating TF-bearing microparticles can be measured in plasma samples from patients with advanced cancer. We are currently using an impedance-based flow cytometer to accurately size and enumerate TF-bearing microparticles to explore the association between cancer thrombosis and elevations in circulating TF-bearing microparticles.

引用

页码：195 / 198

页数：4

共 39 条

[1] Circulating platelet-derived microparticles with procoagulant activity may be a potential cause of thrombosis in uremic patients [J].