The Long and Short of MicroRNAs in the Kidney

被引：44

作者：

Ho, Jacqueline ^{[1
,2
]}

Kreidberg, Jordan A. ^{[3
,4
,5
]}

机构：

[1] UPMC, Childrens Hosp Pittsburgh, Div Nephrol, Rangos Res Ctr, Pittsburgh, PA 15224 USA

[2] Univ Pittsburgh, Sch Med, Dept Pediat, Div Nephrol, Pittsburgh, PA 15261 USA

[3] Harvard Univ, Sch Med, Dept Med, Childrens Hosp Harvard, Boston, MA USA

[4] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[5] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2012年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

INDUCED COLLAGEN EXPRESSION; GENE-REGULATION; SMALL RNAS; TARGET; PROTEIN; DELETION; PATTERNS; MIR-192; MODEL; SITES;

D O I：

10.1681/ASN.2011080797

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

100201 [内科学]; 100221 [泌尿外科学];

摘要：

MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physiology, and pathophysiology. Understanding the function of miRNAs in the kidney may lead to innovative approaches to renal disease.

引用

收藏

页码：400 / 404

页数：5

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