Polymorphisms IL10-819 and TLR-2 are potentially associated with sepsis in brazilian patients

被引：19

作者：

Carregaro, Fernanda ^{[1
]}

Carta, Adriana ^{[3
]}

Cordeiro, Jose Antonio ^{[4
]}

Lobo, Suzana M. ^{[3
]}

Tajara, Eloiza H. ^{[2
,5
]}

Leopoldino, Andreia M. ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin, BR-14040903 Ribeirao Preto, SP, Brazil

[2] Univ Sao Paulo, Inst Biociencias, Dept Genet & Biol Evolut, BR-14040903 Ribeirao Preto, SP, Brazil

[3] Fac Med Sao Jose do Rio Preto, Hosp Base, Sao Jose Do Rio Preto, SP, Brazil

[4] Fac Med Sao Jose do Rio Preto, Dept Epidemiol, Sao Jose Do Rio Preto, SP, Brazil

[5] Fac Med Sao Jose do Rio Preto, Dept Biol Mol, Sao Jose Do Rio Preto, SP, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2010年 / 105卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

cytokines; outcome; SNP; septicaemia; immune system; HARDY-WEINBERG EQUILIBRIUM; G/A POLYMORPHISM; ORGAN FAILURE; SEPTIC SHOCK; TNF-ALPHA; GENE; CD14; INFLAMMATION; SEVERITY; RISK;

D O I：

10.1590/S0074-02762010000500008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程]; 100103 [病原生物学];

摘要：

Genetic variation in immune response is probably involved in the progression of sepsis and mortality in septic patients. However, findings in the literature are sometimes conflicting or their significance is uncertain. Thus, we investigated the possible association between 12 polymorphisms located in the interleukin-6 (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-alpha and tumor necrosis factor-beta (lymphotoxin alpha -LTA) genes and sepsis. Critically ill patients classified with sepsis, severe sepsis and septic shock and 207 healthy volunteers were analyzed and genotyped. Seven of the nine polymorphisms showed similar distributions in allele frequencies between patients and controls. Interestingly, our data suggest that the IL10-819 and TLR-2 polymorphisms may be potential predictors of sepsis.

引用

页码：649 / 656

页数：8

共 48 条

[1]

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].

Arbour, NC ;

Lorenz, E ;

Schutte, BC ;

Zabner, J ;

Kline, JN ;

Jones, M ;

Frees, K ;

Watt, JL ;

Schwartz, DA .

NATURE GENETICS, 2000, 25 (02) :187-+

[2]

DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS [J].

BONE, RC ;

BALK, RA ;

CERRA, FB ;

DELLINGER, RP ;

FEIN, AM ;

KNAUS, WA ;

SCHEIN, RMH ;

SIBBALD, WJ .

CHEST, 1992, 101 (06) :1644-1655

[3]

Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome [J].

Child, NJA ;

Yang, IA ;

Pulletz, MCK ;

de Courcy-Golder, K ;

Andrews, AL ;

Pappachan, VJ ;

Holloway, JW .

BIOCHEMICAL SOCIETY TRANSACTIONS, 2003, 31 :652-653

[4]

Quantification of the power of Hardy-Weinberg equilibrium testing to detect genotyping error [J].

Cox, DG ;

Kraft, P .

HUMAN HEREDITY, 2006, 61 (01) :10-14

[5]

Crow JF, 1999, GENETICS, V152, P821

[6]

Association of IL-10 polymorphism with severity of illness in community acquired pneumonia [J].

Gallagher, PM ;

Lowe, G ;

Fitzgerald, T ;

Bella, A ;

Greene, CM ;

McElvaney, NG ;

O'Neill, SJ .

THORAX, 2003, 58 (02) :154-156

[7]

-308GA and TNFB polymorphisms in acute respiratory distress syndrome [J].

Gong, MN ;

Zhou, W ;

Williams, PL ;

Thompson, BT ;

Pothier, L ;

Boyce, P ;

Christiani, DC .

EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (03) :382-389

[8]

Susceptibility to primary Epstein-Barr virus infection is associated with interleukin-10 gene promoter polymorphism [J].

Helminen, ME ;

Kilpinen, S ;

Virta, M ;

Hurme, M .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (06) :777-780

[9]

Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit [J].

Henckaerts, Liesbet ;

Nielsen, Kaspar R. ;

Steffensen, Rudi ;

Van Steen, Kristel ;

Mathieu, Chantal ;

Giulietti, Annapaula ;

Wouters, Pieter J. ;

Milants, Ilse ;

Vanhorebeek, Ilse ;

Langouche, Lies ;

Vermeire, Severine ;

Rutgeerts, Paul ;

Thiel, Steffen ;

Wilmer, Alexander ;

Hansen, Troels Krarup ;

Van den Berghe, Greet .

CRITICAL CARE MEDICINE, 2009, 37 (01) :192-201

[10]

Genetic polymorphisms in sepsis and septic shock - Role in prognosis and potential for therapy [J].

Holmes, CL ;

Russell, JA ;

Walley, KR .

CHEST, 2003, 124 (03) :1103-1115

← 1 2 3 4 5 →