Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia

被引：29

作者：

Ito, Y

机构：

[1] Laboratory of Cell Regulation, Institute for Virus Research, Kyoto University, Shogoin, Sakyo-ku

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1996年 / 122卷 / 05期

关键词：

heterodimer; AML; ALL; t(8; 21); t(3; t(12; inv(16);

D O I：

10.1007/BF01261402

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Polyomavirus enhancer binding protein 2 (PEBP2), also called core binding factor (CBF), is a heterodimer composed of the alpha and the beta subunits. Structural alterations of each of the two subunits generated by recurrent chromosome translocations/inversion are associated with acute myeloid leukemia or acute lymphoblastic leukemia. Chimeric proteins containing a part of either the alpha or the beta subunits have a potential to affect the transcriptional regulation through the PEBP2/CBF site. Structure and function of PEBP2/CBF and possible mechanisms of leukemogenesis caused by the chimeric proteins are summarized.

引用

收藏

页码：266 / 274

页数：9

相关论文

共 46 条

[1] POLYOMA REGULATORY REGION - A POTENTIAL PROBE FOR MOUSE-CELL DIFFERENTIATION [J].

AMATI, P .

CELL, 1985, 43 (03) :561-562

[2] A POLYOMAVIRUS ENHANCER-BINDING PROTEIN, PEBP5, RESPONSIVE TO 12-O-TETRADECANOYLPHORBOL-13-ACETATE BUT DISTINCT FROM AP-1 [J].

ASANO, M ;

MURAKAMI, Y ;

FURUKAWA, K ;

YAMAGUCHIIWAI, Y ;

SATAKE, M ;

ITO, Y .

JOURNAL OF VIROLOGY, 1990, 64 (12) :5927-5938

[3]

BAE SC, 1993, ONCOGENE, V8, P809

[4] CLONING, MAPPING AND EXPRESSION OF PEBP2-ALPHA-C, A 3RD GENE ENCODING THE MAMMALIAN RUNT DOMAIN [J].

BAE, SC ;

TAKAHASHI, E ;

ZHANG, YW ;

OGAWA, E ;

SHIGESADA, K ;

NAMBA, Y ;

SATAKE, M ;

ITO, Y .

GENE, 1995, 159 (02) :245-248

[5] PEBP2-ALPHA-B/MOUSE AML1 CONSISTS OF MULTIPLE ISOFORMS THAT POSSESS DIFFERENTIAL TRANSACTIVATION POTENTIALS [J].

BAE, SC ;

OGAWA, E ;

MARUYAMA, M ;

OKA, H ;

SATAKE, M ;

SHIGESADA, K ;

JENKINS, NA ;

GILBERT, DJ ;

COPELAND, NG ;

ITO, Y .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (05) :3242-3252

[6] LEUKEMIA DROSOPHILA HOMOLOGY [J].

DAGA, A ;

TIGHE, JE ;

CALABI, F .

NATURE, 1992, 356 (6369) :484-484

[7]

ERICKSON P, 1992, BLOOD, V80, P1825

[8] ASSEMBLY AND FUNCTION OF A TCR-ALPHA ENHANCER COMPLEX IS DEPENDENT ON LEF-1-INDUCED DNA BENDING AND MULTIPLE PROTEIN-PROTEIN INTERACTIONS [J].

GIESE, K ;

KINGSLEY, C ;

KIRSHNER, JR ;

GROSSCHEDL, R .

GENES & DEVELOPMENT, 1995, 9 (08) :995-1008

[9] FUSION OF PDGF RECEPTOR-BETA TO A NOVEL ETS-LIKE GENE, TEL, IN CHRONIC MYELOMONOCYTIC LEUKEMIA WITH T(512) CHROMOSOMAL TRANSLOCATION [J].

GOLUB, TR ;

BARKER, GF ;

LOVETT, M ;

GILLILAND, DG .

CELL, 1994, 77 (02) :307-316

[10] FUSION OF THE TEL GENE ON 12P13 TO THE AML1 GENE ON 21Q22 IN ACUTE LYMPHOBLASTIC-LEUKEMIA [J].

GOLUB, TR ;

BARKER, GF ;

BOHLANDER, SK ;

HIEBERT, SW ;

WARD, DC ;

BRAYWARD, P ;

MORGAN, E ;

RAIMONDI, SC ;

ROWLEY, JD ;

GILLILAND, DG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4917-4921

← 1 2 3 4 5 →