Les liaisons dangereuses

被引：5

作者：

Malissen, B ^{[1
]}

机构：

[1] Univ Med, CNRS, INSERM, Ctr Immunol Marseille Luminy, F-13288 Marseille 9, France

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 03期

关键词：

D O I：

10.1038/85243

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A minimal half-life of the TCR-pMHC interaction is required for complete T cell signaling (the kinetic proof reading model). In an extension to this model it is clear that the dwell time or half-life of TCR-pMHC interaction is also critical for T cell activation

引用

页码：196 / 198

页数：3

共 13 条

[1] Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands [J].

Alam, SM ;

Davies, GM ;

Lin, CM ;

Zal, T ;

Nasholds, W ;

Jameson, SC ;

Hogquist, KA ;

Gascoigne, NRJ ;

Travers, PJ .

IMMUNITY, 1999, 10 (02) :227-237

[2]

Bachmann MF, 1998, EUR J IMMUNOL, V28, P2571, DOI 10.1002/(SICI)1521-4141(199808)28:08<2571::AID-IMMU2571>3.0.CO

[3]

2-T

[4] Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: Implications for TCR signaling [J].

Baker, BM ;

Gagnon, SJ ;

Biddison, WE ;

Wiley, DC .

IMMUNITY, 2000, 13 (04) :475-484

[5] Thermodynamics of T cell receptor binding to peptide-MHC: Evidence for a general mechanism of molecular scanning [J].

Boniface, JJ ;

Reich, Z ;

Lyons, DS ;

Davis, MM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11446-11451

[6] A functional hot spot for antigen recognition in a superagonist TCR/MHC complex [J].

Degano, M ;

Garcia, KC ;

Apostolopoulos, V ;

Rudolph, MG ;

Teyton, L ;

Wilson, IA .

IMMUNITY, 2000, 12 (03) :251-261

[7] The Immunological Synapse: A Molecular Machine Controlling T Cell Activation [J].

Grakoui, Arash ;

Bromley, Shannon K. ;

Sumen, Cenk ;

Davis, Mark M. ;

Shaw, Andrey S. ;

Allen, Paul M. ;

Dustin, Michael L. .

JOURNAL OF IMMUNOLOGY, 2015, 194 (09) :221-227

[8] T cell receptor-MHC interactions up close [J].

Hennecke, J ;

Wiley, DC .

CELL, 2001, 104 (01) :1-4

[9] In vitro evolution of a T cell receptor with high affinity for peptide/MHC [J].

Holler, PD ;

Holman, PO ;

Shusta, EV ;

O'Herrin, S ;

Wittrup, KD ;

Kranz, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5387-5392

[10] Efficient cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex [J].

Kalergis, AM ;

Boucheron, N ;

Doucey, MA ;

Palmieri, E ;

Goyarts, EC ;

Vegh, Z ;

Luescher, IF ;

Nathenson, SG .

NATURE IMMUNOLOGY, 2001, 2 (03) :229-234

← 1 2 →