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Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage

被引：485
作者：
Grivennikov, Sergei I.
Karin, Michael [1 ,2 ]
机构：
[1] Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, Sch Med, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pathol, Sch Med, La Jolla, CA 92093 USA
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2011年 / 70卷
基金：
美国国家卫生研究院;
关键词：
INTESTINAL EPITHELIAL-CELLS; COLITIS-ASSOCIATED CANCER; NF-KAPPA-B; HEPATOCELLULAR-CARCINOMA; STAT3; ACTIVATION; BOWEL-DISEASE; COLON-CANCER; MOUSE MODEL; IN-VIVO; COMPENSATORY PROLIFERATION;
D O I：
10.1136/ard.2010.140145
中图分类号：
R5 [内科学];
学科分类号：
100201 [内科学];
摘要：
Up to 20% of all cancers arise in association with chronic inflammation and most, if not all, solid tumours contain inflammatory infiltrates. Immune cells have a broad impact on tumour initiation, growth and progression and many of these effects are mediated by proinflammatory cytokines. Among these cytokines, the pro-tumourogenic function of tumour necrosis factor (TNF) and interleukin 6 (IL-6) is well established. The role of TNF and IL-6 as master regulators of tumour-associated inflammation and tumourigenesis makes them attractive targets for adjuvant treatment in cancer
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收藏
页码：I104 / I108
页数：5
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