Recognition in molecularly imprinted polymer alpha(2)-adrenoreceptor mimics

被引:27
作者
Berglund, J
Nicholls, IA
Lindbladh, C
Mosbach, K
机构
[1] LUND UNIV,DEPT PURE & APPL BIOCHEM,S-22100 LUND,SWEDEN
[2] UNIV KALMAR,DEPT NAT SCI,S-39129 KALMAR,SWEDEN
关键词
D O I
10.1016/0960-894X(96)00406-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Molecularly imprinted polymers (MIPs) selective for the alpha(2)-adrenoreceptor antagonist yohimbine (1) have been prepared and studied as alpha(2)-adrenoreceptor mimics. Marked ligand stereoselectivity was demonstrated in radioligand binding and HPLC studies upon comparison to blank and corynanthine (2) MIPs. K-D values in the nanomolar range have been shown for anti-1 MIP prepared in chloroform solutions upon rebinding in organic media. Copyright (C) 1996 Published by Elsevier Science Ltd
引用
收藏
页码:2237 / 2242
页数:6
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