Molecular and genomic analysis of genes encoding surface-anchored proteins from Clostridium difficile

被引：70

作者：

Karjalainen, T

Waligora-Dupriet, AJ

Cerquetti, M

Spigaglia, P

Maggioni, A

Mauri, P

Mastrantonio, P

机构：

[1] Ist Super Sanita, Batteriol & Micol Med Lab, I-00161 Rome, Italy

[2] Univ Paris Sud, Fac Pharm, Dept Microbiol, F-92296 Chatenay Malabry, France

[3] CNR, Ist Tecnol Biomed Avanzate, I-20090 Segrate Milan, Italy

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 05期

关键词：

D O I：

10.1128/IAI.69.5.3442-3446.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The gene slpA, encoding the S-layer precursor protein in the virulent Clostridium difficile strains C253 and 79-685, was identified. The precursor protein carries a C-terminal highly conserved anchoring domain, similar to the one found in the Cwp66 adhesin (previously characterized in strain 79-685), an SLH domain, and a variable N-terminal domain mediating cell adherence. The genes encoding the S-layer precursor proteins and the Cwp66 adhesin are present in a genetic locus carrying 17 open reading frames, Ii of which encode a similar two-domain architecture, likely to include surface-anchored proteins.

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页码：3442 / 3446

页数：5

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