Synthesis of unprotected and borane-protected cyclic phosphines using Ru- and Mo-based olefin metathesis catalysts

被引：19

作者：

Slinn, CA

Redgrave, AJ

Hind, SL

Edlin, C

Nolan, SP

Gouverneur, V

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England

[3] Univ New Orleans, Dept Chem, New Orleans, LA 70148 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 21期

关键词：

D O I：

10.1039/b306940k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ru- and Mo-based catalysts can be used in ring closing metathesis (RCM) reactions to synthesise cyclic phosphines protected as their borane complexes. The compatibility of the Schrock Mo-catalyst and the N-heterocyclic carbene Ru- catalysts with this class of substrates is particularly noteworthy as asymmetric RCM (ARCM) is now emerging as a new tool for the preparation of homochiral phosphines. One of the key results is that the Mo-catalyst allows the ring closure of the unprotected diallylphenylphosphine with 95% conversion.

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页码：3820 / 3825

页数：6

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