Oxidation of guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insight from oxygen-18 labeling experiments

被引：65

作者：

Crean, C

Geacintov, NE

Shafirovich, V

机构：

[1] NYU, Dept Chem, New York, NY 10003 USA

[2] NYU, Radiat & Solid State Lab, New York, NY 10003 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 32期

关键词：

DNA damage; isotopic labeling; oxidation radical reactions; reaction mechanisms;

D O I：

10.1002/anie.200500991

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Under oxidative stress: The oxidation of guanine and 8-oxo-7,8-dihydroguanine has been monitored by 18O-labeling methods. The combination of nucleobase radicals 1 with the carbonate radical anion 2 results in the net transfer of O- from CO3.- to the end products (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：5057 / 5060

页数：4

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