Hydra and Niccolo!Paganini (1782-1840) -: two peas in a pod?: The molecular basis of extracellular matrix structure in the invertebrate, Hydra

被引:37
作者
Sarras, MP
Deutzmann, R
机构
[1] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA
[2] Univ Regensburg, Inst Biochem 1, D-8400 Regensburg, Germany
关键词
D O I
10.1002/bies.1101
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The body wall of Hydra is organized as an epithelial bilayer with an intervening extracellular matrix (ECM). Molecular and biochemical analyses of Hydra ECM have established that it contains components similar to those seen in more complicated vertebrates such as human. In terms of biophysical parameters, Hydra ECM is highly flexible; a property that facilitates continuous movements along the organism's longitudinal and radial axis. A more rigid ECM, as in vertebrates, would not be compatible with this degree of movement. The flexible nature of Hydra ECM can now be explained in part by the unique structure of the organism's collagens. Interestingly, some aspects of the structural features of Hydra collagens mimic what is seen in Ehlers-Danlos syndrome, an inherited condition in humans that results in an abnormally flexible ECM that can be debilitating in extreme cases. This review will focus on structure-function relationships of the ECM of Hydra. (C) 2001 John Wiley & Sons, Inc.
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页码:716 / 724
页数:9
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