Crosstalk between the EGFR and LIN-12/Notch pathways in C-elegans vulval development

被引:203
作者
Yoo, AS
Bais, C
Greenwald, I
机构
[1] Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, Dept Biochem & Mol Biophys, New York, NY 10032 USA
[2] Columbia Univ Coll Phys & Surg, Integrated Program Cellular Mol & Biophys Studies, New York, NY 10032 USA
关键词
D O I
10.1126/science.1091639
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The Caenorhabditis elegans vulva is an important paradigm for cell-cell interactions in animal development. The fates of six vulval precursor cells are patterned through the action of the epidermal growth factor receptor - mitogen-activated protein kinase (EGFR-MAPK) inductive signaling pathway, which specifies the 1degrees fate, and the LIN-12/Notch lateral signaling pathway, which specifies the 2degrees fate. Here, we provide evidence that the inductive signal is spatially graded and initially activates the EGFR-MAPK pathway in the prospective 2degrees cells. Subsequently, this effect is counteracted by the expression of multiple new negative regulators of the EGFR-MAPK pathway, under direct transcriptional control of the LIN-12-mediated lateral signal.
引用
收藏
页码:663 / 666
页数:4
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