A catalytic asymmetric synthesis of a versatile intermediate for phorbol derivatives

被引：17

作者：

Sato, H ^{[1
]}

Kim, YS ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 15期

关键词：

cyclopropanation; asymmetric addition; nitrile oxide cycloaddition;

D O I：

10.1016/S0040-4039(99)00340-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A catalytic asymmetric cyclopropanation of enol silyl ether 9 gave the lactone 3 in up to 78% ee. The lactone 3 was then transformed into 2, potentially a very versatile intermediate for phorbol analogs, using an intramolecular nitrile oxide cycloaddition as a key step. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2973 / 2976

页数：4

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