Idiopathic recurrent acute pericarditis: familial Mediterranean fever mutations and disease evolution in a large cohort of Caucasian patients

被引:42
作者
Brucato, A
Shinar, Y
Brambilla, G
Robbiolo, L
Ferrioli, G
Patrosso, MC
Zanni, D
Penco, S
Boiani, E
Ghirardello, A
Cafori, ALP
Bergantin, A
Tombini, V
Moreo, A
Ashtamkar, L
Doria, A
Shoenfeld, Y
Livneh, A
机构
[1] Osped Niguarda Ca Granda, Dept Med, Milan, Italy
[2] Osped Niguarda Ca Granda, Dept Cardiol, Milan, Italy
[3] Osped Niguarda Ca Granda, Dept Immunohematol & Transfus Med, Milan, Italy
[4] Osped Niguarda Ca Granda, Med Genet Dept Diagnost, Milan, Italy
[5] Osped Niguarda Ca Granda, Dept Phys Med, Milan, Italy
[6] Univ Padua, Dept Cardiol, I-35100 Padua, Italy
[7] Univ Padua, Dept Rheumatol, I-35100 Padua, Italy
[8] Chaim Sheba Med Ctr, Heller Inst Med Res, IL-52621 Tel Hashomer, Israel
[9] Ctr Autoimmune Dis, Dept Med B, Tel Hashomer, Israel
关键词
familial Mediterranean fever; MEFV; pericardial disease; pericarditis; Sjogren's syndrome;
D O I
10.1191/0961203305lu2197oa
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Idiopathic recurrent acute pericarditis (IRAP) is suspected to be an autoimmune phenomenon. We studied 46 consecutive patients. We looked for: 1) the occurrence of new diagnoses of autoimmune diseases during our follow up; 2) HLA typing; and 3) the presence of the most frequent mutations linked to familial Mediterranean fever (FMF gene or MEFV). HLA typing was done in 21 patients at loci B, DRB1, DQA1 and DQB1. MEFV gene was looked in 23 patients using specific primers. During the follow-up we made a new diagnosis of primary Sjogren's syndrome in four patients (8.7%) and of rheumatoid arthritis in one patient (2.2%). HLA B14, DRBI*01 and DQB1*0202 were significantly more prevalent, but we did not find a typical HLA typing. MEFV gene was searched: exon 10 was checked by sequence and the E148Q mutation by restriction site analysis. No mutations were found. In conclusion, the prevalence of definite immunorheumatological diseases and the absence of the mutations linked to FMF reinforce the notion that idiopathic acute recurrent pericarditis is an autoinmune condition.
引用
收藏
页码:670 / 674
页数:5
相关论文
共 32 条
[1]  
Adler Y, 1997, Harefuah, V133, P100
[2]   USEFULNESS OF COLCHICINE IN PREVENTING RECURRENCES OF PERICARDITIS [J].
ADLER, Y ;
ZANDMANGODDARD, G ;
RAVID, M ;
AVIDAN, B ;
ZEMER, D ;
EHRENFELD, M ;
SHEMESH, J ;
TOMER, Y ;
SHOENFELD, Y .
AMERICAN JOURNAL OF CARDIOLOGY, 1994, 73 (12) :916-917
[3]  
ADLER Y, 1999, J NONINVASIVE CARDIO, V3, P65
[4]  
ADORNO D, 1998, HLA 1998, P164
[5]  
Aksentijevich I, 1997, CELL, V90, P797
[6]   Pretreatment with corticosteroids attenuates the efficacy of colchicine in preventing recurrent pericarditis: a multi-centre all-case analysis [J].
Artom, G ;
Koren-Morag, N ;
Spodick, DH ;
Brucato, A ;
Guindo, J ;
Bayes-de-Luna, A ;
Brambilla, G ;
Finkelstein, Y ;
Granel, B ;
Bayes-Genis, A ;
Schwammenthal, E ;
Adler, Y .
EUROPEAN HEART JOURNAL, 2005, 26 (07) :723-727
[7]   Familial Mediterranean fever [J].
Ben-Chetrit, E ;
Levy, M .
LANCET, 1998, 351 (9103) :659-664
[8]   Recurrent idiopathic pericarditis: familial occurrence [J].
Brucato, A ;
Brambilla, G .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2005, 102 (03) :529-529
[9]  
Brucato A, 2004, J AM COLL CARDIOL, V43, P2149, DOI 10.1016/j.jacc.2004.03.007
[10]  
Caforio ALP, 2004, EUR HEART J, V25, P114