Integrating Myc and TGF-β signalling in cell-cycle control

被引：37

作者：

Amati, B ^{[1
]}

机构：

[1] DNAX Res Inst Mol & Cellular Biol Inc, Dept Oncol, Palo Alto, CA 94304 USA

来源：

NATURE CELL BIOLOGY | 2001年 / 3卷 / 05期

关键词：

D O I：

10.1038/35074634

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Expression of the cell cycle inhibitor p15(INK4b) is suppressed by the Myc oncoprotein and induced by transforming growth factor-beta (TGF-beta). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-beta -activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control.

引用

页码：E112 / E113

页数：2

共 18 条

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