Histone modifications: from genome-wide maps to functional insights

被引：37

作者：

van Leeuwen, F ^{[1
]}

van Steensel, B ^{[1
]}

机构：

[1] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

来源：

GENOME BIOLOGY | 2005年 / 6卷 / 06期

关键词：

D O I：

10.1186/gb-2005-6-6-113

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A large number of histone modifications has been implicated in the regulation of gene expression. Together, these modifications have the potential to form a complex combinatorial regulatory code. Genome- wide mapping approaches provide new opportunities to decipher this code, but they may suffer from systematic biases. Integration of datasets and improved technologies will provide the way forward.

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页数：6

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