Ajuba LIM proteins are Snail/Slug corepressors required for neural crest development in Xenopus

被引：101

作者：

Langer, Ellen M. ^{[1
]}

Feng, Yunfeng ^{[1
]}

Zhaoyuan, Hou ^{[2
]}

Rauscher, Frank J., III ^{[2
]}

Kroll, Kristen L. ^{[3
]}

Longmore, Gregory D. ^{[1
,4
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA

[2] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[3] Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA

[4] Washington Univ, Sch Med, Div Hematol, St Louis, MO 63110 USA

来源：

DEVELOPMENTAL CELL | 2008年 / 14卷 / 03期

关键词：

D O I：

10.1016/j.devcel.2008.01.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Snail family transcriptional repressors regulate epithelial mesenchymal transitions during physiological and pathological processes. A conserved SNAG repression domain present in all vertebrate Snail proteins is necessary for repressor complex assembly. Here, we identify the Ajuba family of LIM proteins as functional corepressors of the Snail family via an interaction with the SNAG domain. Ajuba LIM proteins interact with Snail in the nucleus on endogenous E-cadherin promoters and contribute to Snail-dependent repression of E-cadherin. Using Xenopus neural crest as a model of in vivo Snail- or Slug-induced EMT, we demonstrate that Ajuba LIM proteins contribute to neural crest development as Snail/Slug corepressors; and are required for in vivo Snail/Slug function. Because Ajuba LIM proteins are also components of adherens junctions and contribute to their assembly or stability, their functional interaction with Snail proteins in the nucleus suggests that Ajuba LIM proteins are important regulators of epithelia dynamics communicating surface events with nuclear responses.

引用

页码：424 / 436

页数：13

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