Polar photodegradation products of quinolones determined by HPLC/MS/MS

被引:44
作者
Burhenne, J [1 ]
Ludwig, M [1 ]
Spiteller, M [1 ]
机构
[1] Univ Kassel, D-37213 Witzenhausen, Germany
关键词
D O I
10.1016/S0045-6535(98)00525-6
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The photochemical degradation of quinolones in aqueous solution proceeds in two main steps. The first step is the degradation of the piperazine substitution forming 7-amino compounds which are more stable against photolysis than the corresponding parent compound. Further photochemical degradation down to CO2 formed intermediate polar substances. By liquid/liquid partition with chloroform/water, ion exchange chromatography and semipreparative HPLC the polar compounds could be isolated. The structures of the photolytically formed pyridone tri- and dicarboxylic acids were elucidated on the basis of HPLC/MS/MS measurement. Additionally the half-life of the main polar compound, 1-cyclopropyl-pyridone-2,3,5-tricarboxylic acid was analysed by HPLC.
引用
收藏
页码:1279 / 1286
页数:8
相关论文
共 13 条
[1]  
BROWN SA, 1996, J VET PHARMACOL THER, V19, P4
[2]  
Burhenne J, 1997, ENVIRON SCI POLLUT R, V4, P10, DOI 10.1007/BF02986257
[3]   Photolytic degradation of fluoroquinolone carboxylic acids in aqueous solution .2. Isolation and structural elucidation of polar photometabolites [J].
Burhenne, J ;
Ludwig, M ;
Spiteller, M .
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 1997, 4 (02) :61-67
[4]  
GAU W, 1986, ARZNEIMITTEL-FORSCH, V36-2, P1545
[5]   DETERMINATION OF CIPROFLOXACIN (BAY O 9867) IN BIOLOGICAL-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].
GAU, W ;
PLOSCHKE, HJ ;
SCHMIDT, K ;
WEBER, B .
JOURNAL OF LIQUID CHROMATOGRAPHY, 1985, 8 (03) :485-497
[6]   Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater [J].
Hartmann, A ;
Alder, AC ;
Koller, T ;
Widmer, RM .
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1998, 17 (03) :377-382
[7]  
HOOPER DC, 1993, QUINOLONE ANTIMICROB
[8]   Binding of fluoroquinolone carboxylic acid derivatives to clay minerals [J].
Nowara, A ;
Burhenne, J ;
Spiteller, M .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1997, 45 (04) :1459-1463
[9]  
Scheer M., 1987, Vet Med Rev, V2, P90
[10]  
SCHMITTKOPPLIN P, 1998, UNPUB J CHROMATOGR