Off limits - Integrins holding boundaries in somitogenesis

被引：12

作者：

Chong, SW ^{[1
]}

Jiang, YJ ^{[1
]}

机构：

[1] Lab Dev Signalling & Patterning, Inst Mol & Cell Biol, Singapore 138673, Singapore

来源：

TRENDS IN CELL BIOLOGY | 2005年 / 15卷 / 09期

关键词：

D O I：

10.1016/j.tcb.2005.07.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Borders are essential for demarcating repeated structures such as somites during vertebrate development. Two recent articles describe roles for Integrin alpha 5 and its ligand Fibronectin1 in zebrafish anterior intersomitic boundary formation and link them to Notch and Eph-Ephrin pathways in epithelialization of somite boundary cells. Together with these pathways, Integrin alpha 5 and Fibronectin1 orchestrate the orderly formation of somite and later myotome borders. These studies shed light on components downstream of the periodic segmentation mechanism - the 'segmentation clock' in somitogenesis.

引用

页码：453 / 457

页数：5

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