Autocrine activation of human monocyte/macrophages by monocyte-derived microparticles and modulation by PPAR? ligands

被引：36

作者：

Bardelli, C. ^{[1
]}

Amoruso, A. ^{[1
]}

Canova, D. Federici ^{[1
]}

Fresu, L. G. ^{[1
]}

Balbo, P. ^{[2
]}

Neri, T. ^{[3
]}

Celi, A. ^{[3
]}

Brunelleschi, S. ^{[1
,4
]}

机构：

[1] Univ A Avogadro, Dept Med Sci, I-28100 Novara, Italy

[2] Azienda Osped Maggiore Carita, Dept Resp Med, Novara, Italy

[3] Univ Pisa, Lab Resp Cell Biol, Vasc & Cardiothorax Dept, Pisa, Italy

[4] Interdisciplinary Res Ctr Autoimmune Dis IRCAD, Dept Med Sci, Novara, Italy

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 165卷 / 03期

关键词：

Monocyte-derived microparticles; human monocytes; monocyte-derived macrophages; oxy-radical production; inflammatory cytokines; NF-?B; PPAR; rosiglitazone; NF-KAPPA-B; SHED MEMBRANE MICROPARTICLES; RECEPTOR-GAMMA; CYTOKINE RELEASE; TISSUE-FACTOR; ALVEOLAR MACROPHAGES; PROCOAGULANT; MICROVESICLES; EXPRESSION; CELLS;

D O I：

10.1111/j.1476-5381.2011.01593.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND AND PURPOSE Microparticles (MPs), small membrane-bound particles originating from different cell types during activation or apoptosis, mediate intercellular communication, exert pro-coagulant activity and affect inflammation and other pathophysiological conditions. Monocyte-derived MPs have undergone little investigation and, to our knowledge, have never been evaluated for their possible autocrine effects. Therefore, we assessed the ability of monocyte-derived MPs to stimulate human monocytes and monocyte-derived macrophages (MDM).

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页码：716 / 728

页数：13

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