Optical, real-time monitoring of the glomerular filtration rate

被引：35

作者：

Rabito, CA

Chen, Y

Schomacker, KT

Modell, MD

机构：

[1] Massachusetts Gen Hosp, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Boston, MA 02114 USA

[3] DiametRx Inc, Natick, MA 01760 USA

来源：

APPLIED OPTICS | 2005年 / 44卷 / 28期

关键词：

D O I：

10.1364/AO.44.005956

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

An easy and accurate assessment of the renal function is a critical requirement for detecting the initial functional decline of the kidney induced by acute or chronic renal disease. A method for measuring the glomerular filtration rate is developed with the accuracy of clearance techniques and the convenience of plasma creatinine. The renal function is measured in rats as the rate of clearance determined from time-resolved transcutaneous fluorescence measurements of a new fluorescent glomerular filtration agent. The agent has a large dose-safety coefficient and the same space distribution and clearance characteristics as iothalamate. This new approach is a convenient and accurate way to perform real-time measurements of the glomerular filtration rate to detect early kidney disease before the renal function becomes severely and irreversibly compromised. (c) 2005 Optical Society of America.

引用

页码：5956 / 5965

页数：10

共 36 条

[1] a practical method for the measurement of glomerular filtration rate (Insulin clearance) - With an evaluation of the clinical significance of this determination [J].