Markers of inflammation in sarcoidosis: Blood, urine, BAL, sputum, and exhaled gas

被引：50

作者：

Bargagli, E. ^{[1
]}

Mazzi, A. ^{[1
]}

Rottoli, Paola ^{[1
]}

机构：

[1] Univ Siena, Le Scotte Hosp, Dept Clin Med & Immunol Sci, Resp Dis Sect, I-53100 Siena, Italy

来源：

CLINICS IN CHEST MEDICINE | 2008年 / 29卷 / 03期

关键词：

D O I：

10.1016/j.ccm.2008.03.004

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Sarcoidosis is characterized by intense inflammation at the different sites of localization. Many different mediators, such as cytokines, chemokines, and other proteins with various functions, that participate in its complex pathogenesis have been proposed as markers of inflammation. This article examines the principal literature on these different markers analyzed in serum, bronchoalveolar lavage, expired breath, and urine. After many years of research, no single marker sufficiently sensitive and specific for diagnosis of sarcoidosis has yet been found. Greater correlation with clinical parameters is needed and proper validation.

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页码：445 / +

页数：15

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