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Therapeutic failure of trimethoprim sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia

被引：4
作者：
Al-Tawfiq, JA
Sorensen, SJ
Cushing, HE
机构：
[1] Indiana Univ, Hosp Clarian Hlth, Indianapolis, IN 46204 USA
[2] Butler Univ, Coll Pharm, Indianapolis, IN 46208 USA
[3] Indiana Univ, Sch Med, Dept Med, Div Infect Dis, Indianapolis, IN USA
来源：
ANNALS OF PHARMACOTHERAPY | 1999年 / 33卷 / 04期
关键词：
Pneumocystis carinii pneumonia; trimethoprim sulfamethoxazole; human immunodeficiency virus;
D O I：
10.1345/aph.18225
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
OBJECTIVE: TO report a case of failure of treatment of Pneumocystis carinii pneumonia (PCP) with trimethoprim/sulfamethoxazole (TMP/SMX) in a patient with HN infection, despite an adequate serum SMX concentration. CASE SUMMARY: A 52-year-old white man was treated with TMP/SMX for PCP. After discharge he returned to the hospital with worsening of the PCP despite a serum SMX concentration of 60 mu g/mL 18 hours after his last dose of TMP/SMX. DISCUSSION: PCP is one of the most common complications of HIV infection. TMP/SMX is the drug of choice for prophylaxis and treatment. The causes of therapeutic failure with this agent are not well documented. CONCLUSIONS: Alternative therapies to TMP/SMX should be seriously considered if the serum concentrations are therapeutic and the patient is not clinically improved..
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页码：413 / 415
页数：3
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