Development of immune function in the intestine and its role in neonatal diseases

被引：99

作者：

Insoft, RM

Sanderson, IR

Walker, WA

机构：

[1] MASSACHUSETTS GEN HOSP, COMBINED PROGRAM PEDIAT GASTROENTEROL & NUTR, DEV GASTROENTEROL LAB, BOSTON, MA 02114 USA

[2] HARVARD UNIV, SCH MED, BOSTON, MA USA

[3] CHILDRENS HOSP, BOSTON, MA USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 1996年 / 43卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0031-3955(05)70420-X

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The gastrointestinal tract has an essential role in normal immune function. The ontogeny and physiology of neonatal gut immunity are discussed. Because the gastrointestinal tract serves as the portal of entry for many potential antigens, breakdown in mucosal defense mechanisms could lead to potentially life-threatening conditions, such as necrotizing enterocolitis, milk-protein enteropathy, and intestinal infections. Proposed immune-mediated mechanisms and possible treatments for these conditions are reviewed.

引用

页码：551 / +