Stereocontrolled total synthesis of (-)-ephedradine A (orantine)

被引：164

作者：

Kurosawa, W ^{[1
]}

Kan, T ^{[1
]}

Fukuyama, T ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 27期

关键词：

D O I：

10.1021/ja036011k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The stereocontrolled total synthesis of (-)-ephedradine A has been accomplished. The synthesis features an asymmetric C-H insertion reaction, an intramolecular ester-amide exchange reaction, and a Sharpless asymmetric aminohydroxylation reaction. Construction of the complex macrocyclic ring was performed by Ns-strategy and an intramolecular aza-Wittig reaction. Copyright © 2003 American Chemical Society.

引用

页码：8112 / 8113

页数：2

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