Pancreatic islet cell transplant for treatment of diabetes

被引:34
作者
Florina, Paolo
Secchi, Antonio
机构
[1] Ist Sci San Raffaele, I-20132 Milan, Italy
[2] Harvard Univ, Sch Med, Childrens Hosp, Brigham & Womens Hosp,Transplantat Res Ctr, Boston, MA 02115 USA
[3] Univ Vita Salute, I-20132 Milan, Italy
[4] Harvard Univ, Stem Cell Inst, Boston, MA 02115 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.ecl.2007.07.004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Islet cell transplantation recently has emerged as one the most promising therapeutic approaches to improving glycometabolic control in type I diabetic patients, and, in many cases, to obtaining insulin independence. Islet cell transplantation requires a relatively short hospital stay and has the advantage of being a relatively noninvasive procedure. The rate of insulin independence I year after islet cell transplantation has improved significantly in recent years (60% at 1 year after transplantation compared to the 15% in the past years). Data from a recent international trial confirmed that islet cell transplantation potentially can be a cure for type 1 diabetes. Recent data indicate that insulin independence after islet cell transplantation is associated with an improvement in glucose metabolism and quality of life and with a reduction in hypoglycemic episodes. Islet cell transplantation is still in its initial stages, and many obstacles still need to be overcome. Once clinical islet transplantation has been established, this treatment could be offered to diabetic patients long before the onset of diabetic complications or to patients with life-threatening hypoglycemic unawareness and brittle diabetes.
引用
收藏
页码:999 / +
页数:16
相关论文
共 79 条
[1]  
Alejandro R, 1995, TRANSPLANT P, V27, P3158
[2]  
Bailes B.K., 2002, AORN J, V76, P266, DOI [DOI 10.1016/S0001-2092(06)61065-X, 10.1016/S0001-2092(06)61065-X]
[3]  
Bailes Barbara K, 2002, AORN J, V76, P266
[4]  
BAILES BK, 2002, AORN J, V76, P283
[5]  
BALLINGER WF, 1972, SURGERY, V72, P175
[6]   Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets [J].
Bell, E ;
Cao, XP ;
Moibi, JA ;
Greene, SR ;
Young, R ;
Trucco, M ;
Gao, ZY ;
Matschinsky, FM ;
Deng, SP ;
Markman, JF ;
Naji, A ;
Wolf, BA .
DIABETES, 2003, 52 (11) :2731-2739
[7]   Glycemic treatment [J].
Bloomgarden, ZT .
DIABETES CARE, 2004, 27 (05) :1227-1234
[8]   Diabetes complications [J].
Bloomgarden, ZT .
DIABETES CARE, 2004, 27 (06) :1506-1514
[9]   Microencapsulated pancreatic islet allografts into nonimmunosuppressed patients with type 1 diabetes - First two cases [J].
Calafiore, R ;
Basta, G ;
Luca, G ;
Lemmi, A ;
Montanucci, MP ;
Calabrese, G ;
Racanicchi, L ;
Mancuso, F ;
Brunetti, P .
DIABETES CARE, 2006, 29 (01) :137-138
[10]   Effects of proinsulin C-peptide in experimental diabetic neuropathy - Vascular actions and modulation by nitric oxide synthase inhibition [J].
Cotter, MA ;
Ekberg, K ;
Wahren, J ;
Cameron, NE .
DIABETES, 2003, 52 (07) :1812-1817