Functional determinants by which snake and cone snail toxins block the α7 neuronal nicotinic acetylcholine receptors

被引：37

作者：

Servent, D

Thanh, HL

Antil, S

Bertrand, D

Corringer, PJ

Changeux, JP

Menez, A

机构：

[1] CEA Saclay, Dept Ingn & Etud Prot, F-91191 Gif Sur Yvette, France

[2] CMU, Dept Physiol, CH-1211 Geneva 4, Switzerland

[3] Inst Pasteur, Mol Neurobiol Lab, F-75724 Paris 15, France

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 02期

关键词：

nicotinic acetylcholine receptors; snake curaremimetic toxins; alpha-conotoxins;

D O I：

10.1016/S0928-4257(98)80146-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Snakes and cone snails produce toxins which block muscular and/or neuronal nicotinic acetylcholine receptors (AChRs). This paper mostly focuses on the determinants by which a snake long chain curaremimetic toxin and the cone snail toxin ImI bind specifically to the alpha 7 neuronal receptor. In both cases, the site involves a small turn-like structure constrained by two half-cystines. ((C) Elsevier, Paris).

引用

页码：107 / 111

页数：5

共 22 条

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BETZEL C, 1991, J BIOL CHEM, V266, P21530

[2] IDENTIFICATION OF A NEW COMPONENT OF THE AGONIST BINDING-SITE OF THE NICOTINIC ALPHA-7 HOMOOLIGOMERIC RECEPTOR [J].