A virus finds its natural killer

被引：4

作者：

Casanova, JL ^{[1
]}

Jouanguy, E ^{[1
]}

Abel, L ^{[1
]}

机构：

[1] Univ Paris Rene Descartes, Lab Human Genet Infect Dis, Necker Enfants Malad Med Sch, INSERM,U550, F-75015 Paris, France

来源：

NATURE GENETICS | 2001年 / 28卷 / 01期

关键词：

D O I：

10.1038/ng0501-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

It has been suggested that natural killer (NK) cells contribute to host defense against infections, but genetic evidence has been lacking. A new study of mouse strains susceptible to infection by cytomegalovirus indicates that the Klra8 (formerly Ly49H) stimulatory receptor is essential to resisting the virus. Such a receptor may have evolved as a response of NK cells to viral strategies to evade the immune system.

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页码：7 / 9

页数：3

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