The role of tetraspanins in fusion

被引：29

作者：

Fanaei, Marzieh ^{[1
]}

Monk, Peter N. ^{[1
]}

Partridge, Lynda J. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Mol Biol & Biotechnol, Krebs Inst, Sheffield S10 2TN, S Yorkshire, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2011年 / 39卷

关键词：

cell fusion; giant cell; syncytium; tetraspanin-enriched microdomain (TEM); tetraspanin; virus; LEUKEMIA-VIRUS TYPE-1; CELL-FUSION; CD9; MEMBRANE; EGGS; CD81; IDENTIFICATION; SUPERFAMILY; EXPRESSION; PROTEINS;

D O I：

10.1042/BST0390524

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane fusion underlies such important biological processes as virus entry into host cells, intracellular protein trafficking, fertilization, formation of muscle fibres and bone resorption. In addition, pathologies such as osteoporosis and implant rejection have been attributed to aberrant fusion. Members of the tetraspanin protein superfamily have been ascribed multiple roles in membrane biology, forming extensive lateral associations and regulating the function of effector molecules by clustering them in specific areas of the membrane. The present review aims to summarize the experimental evidence for tetraspanin function in different fusion events and highlight common themes.

引用

页码：524 / 528

页数：5

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