Chromosome positional effects of gene expressions after cellular senescence

被引：8

作者：

Chen, HL ^{[1
]}

Lu, CY ^{[1
]}

Hsu, YH ^{[1
]}

Lin, JJ ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Biopharmaceut Sci, Taipei 112, Taiwan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 313卷 / 03期

关键词：

D O I：

10.1016/j.bbrc.2003.11.146

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Normal human fibroblasts stop dividing after a limited number of cell divisions termed cellular senescence. Telomere shortening has been shown to be the main factor that causes cellular senescence, however, the molecular mechanism of how telomere shortening causes cellular senescence is unclear. Here we analyze the relationship between gene expressions and their chromosomal locations during cellular senescence. It appears that the expression of genes located in chromosome 4 is preferentially altered after senescence. Moreover, we identify four chromosomal loci in which gene expressions are affected by senescence. Finally, we show that there is no preferential alteration of telomere-proximal genes during cellular senescence, implying that cellular senescence is not caused by derepression of telomere-proximal genes. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：576 / 586

页数：11

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