Chemosensitivity in vitro to 2-chlorodeoxyadenosine and 9-β-D-arabinofuranosyl-2-fluoroadenine in previously unexposed cases of chronic lymphocytic leukemia

被引：11

作者：

Koski, T

Vilpo, L

Vilpo, J

机构：

[1] Tampere Univ Hosp, Dept Clin Chem, Lab Mol Hematol, FIN-33521 Tampere, Finland

[2] Univ Tampere, Sch Med, FIN-33521 Tampere, Finland

来源：

LEUKEMIA RESEARCH | 1999年 / 23卷 / 03期

关键词：

cytotoxicity; purine analogs; fludarabine; chlorodeoxyadenosine; cladribine; chronic lymphocytic leukemia;

D O I：

10.1016/S0145-2126(98)00169-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The chemosensitivity of leukemia cells, obtained from the peripheral blood of 35 patients with B-cell chronic lymphocytic leukemia, was determined by a leucine-incorporation assay in vitro. There was good correlation between the sensitivities to two purine analogs, 2-chlorodeoxyadenosine and 9-beta-D-arabinofuranosyl-2-fluoroadenine among previously untreated patients when tested at the 80% inhibition level. Previous exposure to chlorambucil did not affect the sensitivity to these compounds. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：277 / 279

页数：3

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