Estrogen dependent signaling in reproductive tissues - A role for estrogen receptors and estrogen related receptors

被引：78

作者：

Gibson, Douglas A. ^{[1
]}

Saunders, Philippa T. K. ^{[1
]}

机构：

[1] Univ Edinburgh, MRC UoE Ctr Reprod Hlth, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2012年 / 348卷 / 02期

基金：

英国医学研究理事会;

关键词：

Estrogen receptor; Estrogen related receptor; Fertility; Cancer; BETA ER-BETA; NORMAL MENSTRUAL-CYCLE; FUNCTION IN-VITRO; FACTOR-KAPPA-B; DIFFERENTIAL EXPRESSION; NUCLEAR RECEPTORS; TRANSCRIPTIONAL ACTIVITY; SELECTIVE AGONISTS; HUMAN ENDOMETRIUM; GENE-EXPRESSION;

D O I：

10.1016/j.mce.2011.09.026

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Estrogens play a fundamental role in the development and normal physiological function of multiple tissue systems and have been implicated in the ontogeny of cancers. The biological effects of estrogens are classically mediated via interaction with cognate nuclear receptors. The relative expression of ER subtypes/variants varies between cells within different tissues and this alters the response to natural and synthetic ligands. This review focuses on the role of estrogen and estrogen related receptors in reproductive tissues. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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页码：361 / 372

页数：12

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