Studies on the synthesis and properties of temperature responsive and biodegradable hydrogels

被引：45

作者：

Sun, LF ^{[1
]}

Zhuo, RX ^{[1
]}

Liu, ZL ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Lab Biomed Polymers, Wuhan 430072, Peoples R China

来源：

MACROMOLECULAR BIOSCIENCE | 2003年 / 3卷 / 12期

关键词：

biodegradation; hydrogel; proteinase K; temperature-responsive;

D O I：

10.1002/mabi.200300012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Novel linear poly(NIPA-co-CL) copolymers have been synthesized by radical copolymerization of N-isopropylacrylamide (NIPA) and 2-methylene-1,3-dioxepane (MDO). The structure of copolymers was confirmed by H-1 NMR and IR spectroscopy. Cross-linked poly(NIPA-co-CL) hydrogels have also been prepared in toluene using N,N'-methylenebisacrylamide as cross-linking agent. The hydrogels thus obtained exhibit good temperature response and are biodegradable in the presence of proteinase K.

引用

页码：725 / 728

页数：4

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