The competitive NMDA antagonist CPP blocks MK-801-elicited popping behavior in mice

被引：7

作者：

Deutsch, SI ^{[1
]}

Rosse, RB ^{[1
]}

Riggs, RL ^{[1
]}

Koetzner, L ^{[1
]}

Mastropaolo, J ^{[1
]}

机构：

[1] GEORGETOWN UNIV,SCH MED,DEPT PSYCHIAT,WASHINGTON,DC

来源：

NEUROPSYCHOPHARMACOLOGY | 1996年 / 15卷 / 04期

关键词：

NMDA receptor; MK-801; popping behaviour; phencyclidine; schizophrenia;

D O I：

10.1016/0893-133X(95)00236-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In the current investigation, the ability of CPP {3-(2-carboxypiperazine-4-yl) propyl-1-phosphate} to elicit mouse popping behaviour in a manner similar to that of MK-801 was studied. Unlike MK-801, CPP (3.2-32 mg/kg) did not elicit any popping. The data show that a reduction in NMDA-mediated neural transmission alone is not sufficient to elicit popping behavior in mice. Moreover, pretreatment of mice with CPP attenuated MK-801's ability to elicit popping. These results suggest that popping requires the channel to be in the ''active'', or open, configuration and that it depends on MK-801's access and binding to its unique site in the hydrophobic channel.

引用

页码：329 / 331

页数：3

共 11 条

[1] CONTRASTING EFFECTS OF THE COMPETITIVE NMDA ANTAGONIST CPP AND THE NONCOMPETITIVE NMDA ANTAGONIST MK-801 ON PERFORMANCE OF AN OPERANT DELAYED MATCHING TO POSITION TASK IN RATS [J].