Adipose-derived stem cells as a new therapeutic modality for ageing skin

被引:121
作者
Kim, Jae-Hong [1 ]
Jung, Minyoung [1 ]
Kim, Hyun-Soo [2 ]
Kim, Yong-Man [3 ]
Choi, Eung-Ho [1 ]
机构
[1] Yonsei Univ, Wonju Coll Med, Dept Dermatol, Wonju 220701, South Korea
[2] Yonsei Univ, Wonju Coll Med, Dept Hematol & Oncol, Wonju 220701, South Korea
[3] FCB Pharmicell Co Ltd, Songnam, South Korea
关键词
adipose-derived stem cell; anti-ageing; regeneration; SECRETORY FACTORS; EXPRESSION; BARRIER;
D O I
10.1111/j.1600-0625.2010.01221.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100227 [皮肤病学];
摘要
Stem cells are undifferentiated cells, which have the important properties of self-renewal and differentiation. Adipose-derived stem cells (ADSC) have relative advantages in accessibility and abundance compared to other kinds of stem cells. Regeneration therapy using ADSC has received attention in the treatment of various dermatologic diseases. In previous studies, ADSC were shown to have antioxidant, whitening and wound-healing effects in the skin through secretion of growth factors and by activating fibroblasts. In this study, we investigated whether ADSC could be used as an anti-ageing therapy, especially by dermal collagen synthesis and angiogenesis. Subcutaneous injection of ADSC significantly increased collagen synthesis in hairless mice, and dermal thickness, collagen density and fibroblast number also increased. In addition, procollagen type I protein and mRNA expression increased, which accounts for the increased dermal collagen density. Angiogenesis, which was visualized by CD31 and NG2 immunofluorescence stains, also increased in ADSC-treated skin. Our results suggest that ADSC therapy may be useful in ageing skin. Its effects are mainly mediated by stimulating collagen synthesis in dermal fibroblasts and increasing angiogenesis.
引用
收藏
页码:383 / 387
页数:5
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