Structure and function of Rho-type molecular switches in plants

被引：81

作者：

Berken, Antje ^{[1
]}

Wittinghofer, Alfred ^{[1
]}

机构：

[1] Max Planck Inst Mol Physiol, Dept Biol Struct, D-44227 Dortmund, Germany

来源：

PLANT PHYSIOLOGY AND BIOCHEMISTRY | 2008年 / 46卷 / 03期

关键词：

Rho of plants; ROP/RAC; three-dimensional structure; rho insert; RopGEF; RopGAP; effector;

D O I：

10.1016/j.plaphy.2007.12.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Molecular switches of the Rho family, in concert with their associated regulators and effectors are well known as important control elements of vital signaling pathways in eucaryotic organisms. Yet, this knowledge has so far been established mainly from animal and fungal studies. However, during the recent years, the Rho switch has gone increasingly green as well, and it turned out that the homologous system in plants holds some distinctive features regarding structures, functions and molecular mechanisms for signal transduction. In this review, we give an overview about the structural characteristics of the Rho proteins of plants, termed ROP, highlighting some exciting differences to their animal and fungal counterparts. We further address the unique regulators and effectors of the ROPs and discuss the structural basis for the function and interaction of those proteins in ROP controlled reaction cascades. We finally intend to stimulate the demand for future three-dimensional structures that advance our understanding of the ROP switch in plants. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：380 / 393

页数：14

共 111 条

[1] Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein [J].

Abdul-Manan, N ;

Aghazadeh, B ;

Liu, GA ;

Majumdar, A ;

Ouerfelli, O ;

Siminovitch, KA ;

Rosen, MK .

NATURE, 1999, 399 (6734) :379-383

[2] Small GTPase 'Rop': molecular switch for plant defense responses [J].

Agrawal, GK ;

Iwahashi, I ;

Rakwal, R .

FEBS LETTERS, 2003, 546 (2-3) :173-180

[3] Directional cell expansion - turning toward actin [J].

Bannigan, A ;

Baskin, TI .

CURRENT OPINION IN PLANT BIOLOGY, 2005, 8 (06) :619-624

[4] Interchangeable functions of Arabidopsis PIROGI and the human WAVE complex subunit SRA1 during leaf epidermal development [J].

Basu, D ;

El-Assal, SED ;

Le, J ;

Mallery, EL ;

Szymanski, DB .

DEVELOPMENT, 2004, 131 (17) :4345-4355

[5]

Bateman A, 2002, NUCLEIC ACIDS RES, V30, P276, DOI [10.1093/nar/gkr1065, 10.1093/nar/gkp985, 10.1093/nar/gkh121]

[6] RopGAP4-dependent Rop GTPase rheostat control of Arabidopsis oxygen deprivation tolerance [J].

Baxter-Burrell, A ;

Yang, ZB ;

Springer, PS ;

Bailey-Serres, J .

SCIENCE, 2002, 296 (5575) :2026-2028

[7] ROPs in the spotlight of plant signal transduction [J].

Berken, A. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (21) :2446-2459

[8] A new family of RhoGEFs activates the Rop molecular switch in plants [J].

Berken, A ;

Thomas, C ;

Wittinghofer, A .

NATURE, 2005, 436 (7054) :1176-1180

[9] Localization of AtROP4 and AtROP6 and interaction with the guanine nucleotide dissociation inhibitor AtRhoGDI1 from Arabidopsis [J].

Bischoff, F ;

Vahlkamp, L ;

Molendijk, A ;

Palme, K .

PLANT MOLECULAR BIOLOGY, 2000, 42 (03) :515-530

[10] Rho GTPases and their effector proteins [J].

Bishop, AL ;

Hall, A .

BIOCHEMICAL JOURNAL, 2000, 348 (02) :241-255

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