Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors

被引：107

作者：

Ludwig, A ^{[1
]}

Rehberg, S ^{[1
]}

Wegner, M ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Biochem, D-91054 Erlangen, Germany

来源：

FEBS LETTERS | 2004年 / 556卷 / 1-3期

关键词：

tyrosinase-related protein 2; dopachrome tautomerase; Sox; Sry; high-mobility group;

D O I：

10.1016/S0014-5793(03)01446-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sox10 regulates melanocyte development at least partly through its stimulatory effect on Mitf gene expression. Here, we characterize the gene for dopachrome tautomerase (Dct/Trp2) as the second direct Sox10 target in melanocytes, arguing for the existence of Sox10 functions in melanocytes that are independent of its epistatic relationship to Mitf. Sox10 responsiveness was mediated by multiple binding sites within the proximal Dct/Trp2 promoter which display varying affinities and bind Sox10 monomers or dimers. Mitf synergistically enhanced Sox10-dependent activation of the Dct/Trp2 promoter. Synergy appears mechanistically complex and requires both direct binding of Sox10 to the promoter and the protein's trans-activation domain. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：236 / 244

页数：9

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