Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis:: Fermentation, isolation and biological activity

被引：55

作者：

Komaki, H

Nemoto, A

Tanaka, Y

Takagi, H

Yazawa, K

Mikami, Y

Shigemori, H

Kobayashi, J

Ando, A

Nagata, Y

机构：

[1] Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chuo Ku, Chiba 260, Japan

[2] Higeta Shoyu Co Ltd, Res Lab, Chiba 2888680, Japan

[3] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

[4] Chiba Univ, Grad Sch Sci & Technol, Dept Biotechnol, Matsudo, Chiba 2718510, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 01期

关键词：

D O I：

10.7164/antibiotics.52.13

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A novel tricyclic diterpenoid antibiotic, brasilicardin A, was isolated from the culture broth of Nocardia brasiliensis IFM 0406. The antibiotic exhibited immunosuppressive activity in a mouse mixed lymphocyte reaction (MLR) assay system and its IC50 value was 0.057 mu g/ml. Although the inhibitory activity of cyclosporin A (CyA) against IL-2 production was confirmed in the MLR assay system, brasilicardin A did not have the activity. The results of in vitro toxicity testing of brasilicardin A against various human cell lines were compared with those of CyA.

引用

页码：13 / 19

页数：7

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