Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma

被引:73
作者
Tomizawa, Y
Kohno, T
Fujita, T
Kiyama, M
Saito, R
Noguchi, M
Matsuno, Y
Hirohashi, S
Yamaguchi, N
Nakajima, T
Yokota, J
机构
[1] Natl Canc Ctr, Res Inst, Div Biol, Chuo Ku, Tokyo 1040045, Japan
[2] Natl Canc Ctr, Res Inst, Div Pathol, Chuo Ku, Tokyo 1040045, Japan
[3] Natl Canc Ctr, Res Inst, Canc Informat & Epidemiol Div, Chuo Ku, Tokyo 1040045, Japan
[4] Gunma Univ, Sch Med, Dept Pathol 2, Gunma 3718511, Japan
[5] Hitachi Ltd, Adv Res Lab, Hatoyama, Saitama 3500395, Japan
[6] Gunma Univ, Sch Med, Dept Internal Med 1, Gunma 3718511, Japan
关键词
stage I NSCLC; p53; mutation; expression; prognosis;
D O I
10.1038/sj.onc.1202384
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The association of p53 abnormalities with the prognosis of patients,vith non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial, Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC, p53 mutations were detected in 49 of 103 (48%) tumors, Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8, Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression,vas only 69%, p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P < 0.001), Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P = 0.243 in null mutations), These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.
引用
收藏
页码:1007 / 1014
页数:8
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