The Role of Endoplasmic Reticulum Stress in Emphysema Results from Cigarette Smoke Exposure

被引：36

作者：

Gan, Guixiang ^{[1
,2
]}

Hu, Ruicheng ^{[1
]}

Dai, Aiguo ^{[1
]}

Tan, Shuangxiang ^{[1
]}

Ouyang, Qing ^{[1
]}

Fu, Daiyan ^{[1
]}

Jiang, Dixuan ^{[1
]}

机构：

[1] Hunan Prov Geriatr Hosp, Dept Resp Med, Hunan Inst Gerontol, Changsha 410016, Hunan, Peoples R China

[2] Univ S China, Grad Sch, Hengyang, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2011年 / 28卷 / 04期

基金：

中国国家自然科学基金;

关键词：

CCAAT/enhancer-binding protein-homologous protein; Caspase-12; Emphysema; Apoptosis; Endoplasmic reticulum stress; OBSTRUCTIVE PULMONARY-DISEASE; UNFOLDED PROTEIN RESPONSE; ER STRESS; MOLECULAR-MECHANISMS; INDUCED APOPTOSIS; GENE-EXPRESSION; CELL-DEATH; LUNG; CASPASE-12; CHOP;

D O I：

10.1159/000335766

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Apoptosis is of considerable importance in the pathogenesis of emphysema, and recent studies show that endoplasmic reticulum (ER) stress is involved in emphysema. In our research, we investigated the role of protein kinase RNA (PKR)-like ER kinase (PERK)/ eukaryotic initiation factor 2 alpha (eIF2 alpha) pathway, the CCAAT enhancer-binding protein-homologous protein (CHOP) expression, caspase-12 activation and apoptosis in emphysema results from cigarette smoke (CS) exposure. Expression of phosphorylated-PERK (p-PERK), phospholated-eIF2 alpha (p-eIF2 alpha), CHOP and caspase-12 as well as the apoptosis rate are remarkably increased in rats after exposure to 2 months CS compared with control rats, significantly elevated in rats exposed to 4 months CS over rats exposed only to 2 months CS, and slightly decreased in ex-smoking rats in contrast to rats exposed to 4 months CS. Taken together, our results show that CS induces ER stress in lung epithelial cells, which may subsequently lead to lung injury in rats, and this might be a novel target for protection of pulmonary epithelial cells from ER stress injury in emphysema. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：725 / 732

页数：8

共 38 条

[1]

Alveolar wall apoptosis causes lung destruction and emphysematous changes [J].