Plasma Concentrations of Angiogenesis-related Molecules in Patients with Pancreatic Cancer

被引：23

作者：

Sakamoto, Hiroki ^{[2
]}

Kimura, Hideharu ^{[1
]}

Sekijima, Masaru ^{[3
]}

Matsumoto, Kazuko ^{[1
]}

Arao, Tokuzo ^{[1
]}

Chikugo, Takaaki ^{[4
]}

Yamada, Yasuhide ^{[5
]}

Kitano, Masayuki ^{[2
]}

Ito, Akihiko ^{[4
]}

Takeyama, Yoshifumi ^{[6
]}

Kudo, Masatoshi ^{[2
]}

Nishio, Kazuto ^{[1
]}

机构：

[1] Kinki Univ, Dept Genome Biol, Sch Med, Osaka 5898511, Japan

[2] Kinki Univ, Dept Gastroenterol & Hepatol, Sch Med, Osaka 5898511, Japan

[3] Mitsubishi Chem Medience Corp, Adv Med Sci Res Ctr, Kamisu, Ibaraki 3140255, Japan

[4] Kinki Univ, Dept Pathol, Sch Med, Osaka 5898511, Japan

[5] Natl Canc Ctr, Dept Med Oncol, Chuo Ku, Tokyo 1040045, Japan

[6] Kinki Univ, Dept Surg, Sch Med, Osaka 5898511, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 42卷 / 02期

关键词：

pancreatic cancer; angiogenesis; plasma; IL-8; ENDOTHELIAL-GROWTH-FACTOR; PHASE-III TRIAL; HIGH EXPRESSION; POOR-PROGNOSIS; GEMCITABINE; INTERLEUKIN-8; BEVACIZUMAB; RECURRENCE; CARCINOMA; DISEASE;

D O I：

10.1093/jjco/hyr178

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Anti-angiogenic agents are now being clinically evaluated for the treatment of pancreatic cancer and a detailed investigation of the angiogenic profile of pancreatic cancer is needed. The aim of this study was to evaluate the plasma concentrations of angiogenesis-related molecules in patients with pancreatic cancer, compared with those with other diseases. Methods: Plasma samples obtained from 45 patients with pancreatic cancer were analyzed and compared with those from 9 patients with pancreatitis, 16 patients with benign hepatobiliary diseases and 58 patients with colorectal cancers. The plasma levels of angiogenesis-related molecules including angiopoietin-2, follistatin, granulocyte-colony stimulating factor, hepatocyte growth factor, interleukin-8, leptin, platelet-derived growth factor beta polypeptide, platelet endothelial cell adhesion molecule-1 and vascular endothelial growth factor were determined using an antibody suspension bead arrays system. Results: The plasma levels of all the angiogenesis-related molecules were not increased in patients with pancreatic cancer, compared with those with pancreatitis and benign hepatobiliary diseases, whereas the levels of those with colorectal cancer were markedly increased. The plasma interleukin-8 concentration was significantly elevated in patients with distant metastases and was associated with a poor treatment outcome of chemotherapy in patients with pancreatic cancer. Conclusions: The plasma levels of angiogenesis-related molecules were not elevated in patients with pancreatic cancer, compared with those with benign diseases or colorectal cancer. The plasma interleukin-8 level may be a novel biomarker for the response to chemotherapy in patients with pancreatic cancer and warrants further prospective study.

引用

页码：105 / 112

页数：8

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