Oxidation of natural targets by dioxiranes.: Part 4:: A novel approach to the synthesis of N-hydroxyamino acids using dioxiranes

被引：16

作者：

Detomaso, A ^{[1
]}

Curci, R ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Chim, Ctr CNR MISO, I-70126 Bari, Italy

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 04期

关键词：

dioxiranes; N-hydroxyamino acids; NH-oxidation; oxidation; chemoselectivity;

D O I：

10.1016/S0040-4039(00)02107-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient approach to the synthesis of N-hydroxyamino acids in high enantiomeric excess is described; this involves the high-yielding selective N-hydroxylation of N-Boc protected primary amino acid esters with methyl(trifluoromethyl)dioxirane under mild conditions. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：755 / 758

页数：4

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