Vertebrate neural cell-fate determination: Lessons from the retina

被引:754
作者
Livesey, FJ
Cepko, CL
机构
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
关键词
D O I
10.1038/35053522
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Postmitotic neurons are produced from a pool of cycling progenitors in an orderly fashion during development. Studies of cell-fate determination in the vertebrate retina have uncovered several fundamental principles by which this is achieved. Most notably, a model for vertebrate cell-fate determination has been proposed that combines findings on the relative roles of extrinsic and intrinsic regulators in controlling cell-fate choices. At the heart of the model is the proposal that progenitors pass through intrinsically determined competence states, during which they are capable of giving rise to a limited subset of cell types under the influence of extrinsic signals.
引用
收藏
页码:109 / 118
页数:10
相关论文
共 100 条
  • [1] cDNA cloning and expression analysis of NeuroD mRNA in human retina
    Acharya, HR
    Dooley, CM
    Thoreson, WB
    Ahmad, I
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 233 (02) : 459 - 463
  • [2] Alexiades MR, 1997, DEVELOPMENT, V124, P1119
  • [3] Alexiades MR, 1996, DEV DYNAM, V205, P293, DOI 10.1002/(SICI)1097-0177(199603)205:3<293::AID-AJA9>3.0.CO
  • [4] 2-D
  • [5] ALTSHULER D, 1993, DEVELOPMENT, V119, P1317
  • [6] Notch signaling: Cell fate control and signal integration in development
    Artavanis-Tsakonas, S
    Rand, MD
    Lake, RJ
    [J]. SCIENCE, 1999, 284 (5415) : 770 - 776
  • [7] AUSTIN CP, 1995, DEVELOPMENT, V121, P3637
  • [8] Hairless promotes stable commitment to the sensory organ precursor cell fate by negatively regulating the activity of the Notch signaling pathway
    Bang, AG
    Bailey, AM
    Posakony, JW
    [J]. DEVELOPMENTAL BIOLOGY, 1995, 172 (02) : 479 - 494
  • [9] Bao ZZ, 1997, J NEUROSCI, V17, P1425
  • [10] Notch signaling directly controls cell proliferation in the Drosophila wing disc
    Baonza, A
    Garcia-Bellido, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (06) : 2609 - 2614