Microwave-induced facile synthesis of water-soluble fluorogenic alginic acid derivatives

被引：37

作者：

Chhatbar, Mahesh U. ^{[1
]}

Meena, Ramavatar ^{[1
]}

Prasad, Kamalesh ^{[1
]}

Chejara, Dharmesh R. ^{[1
]}

Siddhanta, A. K. ^{[1
]}

机构：

[1] Cent Salt & Marine Chem Res Inst, Council Sci & Ind Res, Marine Biotechnol & Ecol Discipline, Bhavnagar 364021, Gujarat, India

来源：

CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 05期

关键词：

Alginic acid; Microwave; Genipin; Cross linking; Fluorescence; FLUORESCENT POLYMER; SODIUM ALGINATE; BLUE PIGMENTS; NITROGEN ATOM; GENIPIN; AMIDE; HYDROLYSIS; GENIPOSIDE; CONJUGATE; CHITOSAN;

D O I：

10.1016/j.carres.2011.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A facile microwave-induced method was developed for synthesizing water-soluble fluorescent derivatives of alginic acid (ALG) with four different diamines, hydrazine (HY), ethylenediamine (EDA), 1,6-hexanediamine (HDA), and 1,4-cyclohexanediamine (CHDA), followed by a cross-linking reaction with a natural cross linker genipin. The ethylenediamine derivative of alginic acid (ALG-EDA) exhibited good fluorescent activity, which upon cross linking was enhanced threefold. The other amide derivatives, for example, ALG-HY. ALG-HDA, and ALG-CHDA, were not fluorescent, but their respective crosslinked products exhibited excellent fluorescent activity. The fluorescence intensity had an inverse correlation with the number of carbon atoms present in the amine, which in turn was a function of degree of substitution (DS). These fluorescent polysaccharide derivatives are of potential utility in the domain of sensor applications. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：527 / 533

页数：7

共 49 条

[1]

ABAD L, 1999, P 15 PHIL CHEM C CEB, P466

[2]

ABRAMOVITCH RA, 1991, ORG PREP PROCED INT, V23, P685

[3]

Synthesis and characterization of a pyrrole-alginate conjugate and its application in a biosensor construction [J].