New approach to solid phase synthesis of polyamide nucleic acids analogues (PNA) and PNA-DNA conjugates

被引：41

作者：

Stetsenko, DA

Lubyako, EN

Potapov, VK

Azhikina, TL

Sverdlov, ED

机构：

[1] Shemyakin-Ovchinnikov Inst. B., Russian Academy of Sciences, 117871 Moscow V-437, Ul. Miklukho-Maklaya

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 20期

关键词：

D O I：

10.1016/0040-4039(96)00624-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New version of sequential DNA and polyamide solid phase synthesis is applied to the preparation of PNA and PNA-DNA conjugates bearing free 3'-end N-Mmt protected uracil and thymine PNA monomers are obtained in high yields. Novel support derived from TSK Gel Toyopearl(R) and efficient coupling procedure with 2,4,6-triisopropylbenzenesulfonyloxy-l-benzotriazole (TPSOBt) are also developed Preliminary results of biological testing of prepared compounds are reported. Copyright (C) 1996 Elsevier Science Ltd

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页码：3571 / 3574

页数：4

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