Palmoplantar keratodermas

被引：71

作者：

Itin, PH

Fistarol, SK

机构：

[1] Univ Basel, Dept Dermatol, CH-4031 Basel, Switzerland

[2] Kantonsspital, Dept Dermatol, CH-5001 Aarau, Switzerland

来源：

CLINICS IN DERMATOLOGY | 2005年 / 23卷 / 01期

关键词：

D O I：

10.1016/j.clindermatol.2004.09.005

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The palmoplantar skin is a highly specialized tissue which is able to resist mechanical trauma and other physical stress. In recent years the more descriptive classification of keratodermas has switched to an exact molecular genetic view where gene functions are considered. Palmoplantar keratodermas can be separated in the following functional subgroups: disturbed gene fuctions in structural proteins (keratins), cornified envelope (loricrin, transglutaminase), cohesion (plakophilin, desmoplakin, desmoglein1), cell-to-cell communication (connexins), and transmembrane signal transduction (cathepsin C). This review intends to emphasize the typical clinical aspects and symptom complexes associated with palmoplantar keratodermas which enable the astute dermatologist to make a clinical diagnosis. In addition the molecular genetic knowledge on the topic is given which is necessary to confirm the clinical diagnosis. (c) 2005 Elsevier Inc. All rights reserved.

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页码：15 / 22

页数：8

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